Grants
Center for Chronic Disorders of Aging
A major initiative of the Center for Chronic Disorders of Aging (CCDA) is to aid in
the development of new studies either by providing pilot grants to investigators studying
chronic diseases/disorders in the aging process or creating collaboration between
CCDA members.
The goals of this initiative are to:
- Increase research within the CCDA and Colleges of Osteopathic Medicine.
- Increase scholarly activity within the 黑料传送门 community.
- Establish preliminary studies for large grant applications to organizations such as
the NIH and NSF.
- Provide recognition of the existence of the CCDA as a unique entity supporting basic
and applied research into healthy aging and major chronic problems of the 21st century.
Major granting agencies include the and the .
Pilot Research Grants
- Cathy J. Hatcher, PhD, Associate Professor of Bio-Medical Sciences; 黑料传送门 鈥� 鈥淐ontributions
of a Novel Cardiac Protein to Coronary Vessel Formation鈥�
- Jocelyn Lippman-Bell, PhD, Assistant Professor of Bio-Medical Sciences; 黑料传送门 鈥� 鈥淐haracterization
and pharmacological targeting of the chronic behavioral consequences of early-life
seizures in zebrafish鈥�
- Heather L. Montie, PhD, Assistant Professor of Bio-Medical Sciences; 黑料传送门 鈥� 鈥淕eneration
and characterization of a zebrafish model of SBMA鈥�
- Lindon Young, PhD, Professor of Bio-Medical Sciences; 黑料传送门 鈥� 鈥淭he effects of PKC epsilon
activator/inhibitor peptides on nitric oxide release and hypoxia/re-oxygenation induced
cell death in human umbilical vein endothelial cells鈥�
- Cathy J. Hatcher, PhD, Assistant Professor of Bio-Medical Sciences; 黑料传送门 鈥� 鈥淎jap 1
in Congenital Defects of Coronary Vessel Formation鈥�
- Abigail Hielscher, PhD, Assistant Professor of Bio-Medical Sciences; 黑料传送门 Georgia
鈥� 鈥淟oss of stromal caveolin-1 on chemotherapy responses of breast tumor cells鈥�
- Jocelyn Lippman-Bell, PhD, Assistant Professor of Bio-Medical Sciences; 黑料传送门 鈥� 鈥淚nvestigating
dendritic spine plasticity after seizures鈥�
- Heather L. Montie, PhD, Assistant Professor of Bio-Medical Sciences; 黑料传送门 鈥� 鈥淒oes
activation of AMPK abrogate SBMA pathogenesis?鈥�
- Mary P. Owen, JD, PhD, Professor of Bio-Medical Sciences; 黑料传送门 Georgia 鈥� 鈥淣ovel Mechanism
Involved in Rapid Testosterone-Induced Vasodilation of Myogenic Tone in Mesenteric
Resistance Microvessels鈥�
- Srujana Rayalam, PhD, Assistant Professor of Pharmaceutical Sciences; 黑料传送门 Georgia
鈥� 鈥淪ynergistic effects of phytochemicals and immunomodulatory glycan LNFPIII on the
beiging of adipocytes: a novel therapeutic approach for obesity鈥�
- Dianzheng Zhang, PhD, Associate Professor of Bio-Medical Sciences; 黑料传送门 鈥� 鈥淭he mechanism
of HP1纬-mediated prostate cancer progression through regulating de novo fatty acid
synthesis鈥�
No pilot grants were awarded this year.
- Vishakha Bhave, PhD, Assistant Professor of Pharmaceutical Sciences; 黑料传送门 Georgia
鈥� 鈥淩ole of bile acid-FXR signaling in hepatocyte to biliary transdifferentiation鈥�
- Cathy Hatcher, PhD, Assistant Professor of Bio-Medical Sciences; 黑料传送门 鈥� 鈥淎 Transgenic
Mouse Model of Ischemic Cardiomyopathy鈥�
- Abigail Hielscher, PhD, Assistant Professor of Bio-Medical Sciences; 黑料传送门 Georgia
鈥� 鈥淭he role of matrix rigidity on morphological and functional characteristics of
human mammary fibroblasts grown in 3D gelatin hydrogels鈥�
- Huo Lu, PhD, Assistant Professor of Bio-Medical Sciences; 黑料传送门 Georgia 鈥� 鈥淪tudy Cerebellar
Nuclei Output to Thalamus Using Autopatch Recording鈥�
- Heather Montie, PhD, Assistant Professor of Bio-Medical Sciences; 黑料传送门 鈥� 鈥淒etermining
the role of SIRT3 in spinal and bulbar muscular atrophy鈥�
- Mei Xu, PhD, Associate Professor of Bio-Medical Sciences; 黑料传送门 鈥� 鈥淢olecular manipulation
to promote axon regeneration鈥�
- Christopher Adams, PhD, Associate Professor of Bio-Medical Sciences; 黑料传送门 鈥� 鈥淏actericidal
Implant Surfaces鈥�
- Vishakha Bhave, PhD, Assistant Professor of Pharmaceutical Sciences; 黑料传送门 Georgia
鈥� 鈥淩ole of programming factors in trans-differentiation of hepatocytes to biliary
epithelial cells鈥�
- Qian Chen, PhD, Research Assistant Professor of Bio-Medical Sciences; 黑料传送门 鈥� 鈥淭he
role of mitochondria in acute hyperglycemia: activation of vascular NADPH oxidase
and eNOS uncoupling鈥�
- Marina D鈥橝ngelo, PhD, Professor of Bio-Medical Sciences; 黑料传送门 鈥� 鈥淒evelopment of an
in vitro, whole tooth model to study effects of endogenous matrix metalloprotease
activity on resin restorations鈥�
- Xinyu Wang PhD, Assistant Professor of Pharmaceutical Sciences; 黑料传送门 Georgia 鈥� 鈥淚nhibitory
effects of caffeic acid phenethyl ester (CAPE) on multiple myeloma cell growth: Nrf2
and NF-kB crosstalk鈥�
- Richard White, PhD, Professor of Basic Science; 黑料传送门 Georgia鈥� 鈥淢echanisms of androgen
regulation of the microvasculature鈥�
- Christopher Adams, PhD, Associate Professor of Anatomy; 黑料传送门 鈥� 鈥淭he mechanism by which
osteoblast maturation regulates calcium and phosphate ion pair-induced apoptosis鈥�
- Brian J. Balin, PhD, Professor of Pathology, Microbiology, Immunology and Forensic
Medicine; 黑料传送门 鈥� 鈥淒etection of Chlamydia pneumoniae in blood samples: A diagnostic
screen for Alzheimer's disease鈥�
- Marcus Bell, PhD, Associate Professor of Neuroscience, Physiology, Pharmacology; 黑料传送门
鈥� 鈥淚nfection with Chlamydia pneumoniae alters calcium-associated gene regulations
and processes in neuronal cells and monocytes: Implications for Alzheimer鈥檚 disease鈥�
Qian Chen, PhD, Research Assistant Professor of Pathology, Microbiology, Immunology
and Forensic Medicine; 黑料传送门 鈥� 鈥淩ole of acute hyperglycemia in myocardial ischemia/reperfusion鈥�
- Marina D鈥橝ngelo, PhD, Professor of Anatomy; 黑料传送门 鈥� 鈥淎ssaying endogenous matrix metalloproteases
(MMPs) in acid-etched, dentinal cavity walls of an extracted tooth 鈥�
- Mandana Ghodrat, PharmD, Assistant Professor of Pharmacy Practice; 黑料传送门 Georgia 鈥�
鈥淩ole of cathepsins D and L as novel markers in acute coronary syndrome in females鈥�
- Lori Hardy, PhD, Associate Professor of Basic Science; 黑料传送门 Georgia 鈥� 鈥淐aMKIIb regulation
of the actin cytoskeleton鈥�
- Ramadevi Nimmanapalli, D Phil, Dipl ACVM, Associate Professor of Pharmaceutical Sciences;
黑料传送门 Georgia 鈥� 鈥淒evelopment of heat shock protein 70 inhibitory antibodies鈥�
- Srujana Rayalam, PhD, Assistant Professor of Pharmaceutical Sciences; 黑料传送门 Georgia
鈥� 鈥淰itamin D and phytochemicals for prevention of obesity and osteoporosis鈥�
- Desuo Wang, PhD, Assistant Professor of Pharmaceutical Sciences; 黑料传送门 Georgia 鈥� 鈥淎ngiotensin
II and glutamate additively or synergistically disrupt the intracellular Ca2+ homeostasis
of astroglia鈥�
- Xinyu (Eric) Wang, PhD, Assistant Professor of Pharmaceutical Sciences; 黑料传送门 Georgia
鈥� 鈥淚nhibitory effects of caffeic acid phenethyl ester (CAPE) on multiple myeloma cell
growth鈥�
- Mei Xu, MD, PhD, Assistant Professor of Anatomy; 黑料传送门 鈥� 鈥淎 functional role of IMP2
in axon regeneration in localizing specific MRNAs鈥�
- Christopher Adams, PhD, Associate Professor of Anatomy; 黑料传送门 鈥� 鈥淭he role of osteoblast
maturation in the regulation of calcium and phosphate ion pair-induced apoptosis鈥�
- Denah M. Appelt, PhD, Professor of Neuroscience, Pharmacology and Physiology; 黑料传送门
鈥� 鈥淎nalysis of autophagy and apoptosis gene regulation in neuronal cells infected
with Chlamydia pneumoniae鈥�
- Stacy Cahn, PhD, Assistant Professor of Psychology; 黑料传送门 鈥� 鈥淧redictors of successful
weight loss following bariatric surgery鈥�
- Qian Chen, PhD, Research Assistant Professor of Pathology, Microbiology, Immunology
and Forensic Medicine; 黑料传送门 鈥� 鈥淭he role of NADPH oxidase and eNOS in acute hyperglycemia-induced
oxidative stress conditions鈥�
- Marina D鈥橝ngelo, PhD, Associate Professor of Anatomy; 黑料传送门 鈥� 鈥淓ffect of BodyJet and
VASER liposuction technique on the validity and differentiation of adipose derived
stem cells 鈥�
- Yue-Qiao (George) Huang, BSC, PhD, Assistant Professor of Pharmaceutical Science;
黑料传送门 Georgia 鈥� 鈥淧rotein synthesis-dependent NMDA receptor trafficking after dopamine
D-1 receptor activation鈥�
- Frank Jenney, PhD, Assistant Professor of Biochemistry; 黑料传送门 Georgia 鈥� 鈥淎melioration
of ischemia/reperfusion injury with an anaerobic enzyme, superoxide reductase鈥�
- John Kermode, PhD, Professor of Pharmaceutical Science; 黑料传送门 Georgia 鈥� 鈥淢eta-analysis
of platelet receptor polymorphisms as risk factors for myocardial infarction and stroke鈥�
- Michael Kuchera, DO, Professor of OMM; 黑料传送门 鈥� 鈥淓xploring the use of intensive osteopathic
lymphatic drainage treatment for loew extremity lymphedema in the elderly鈥�
- Ramadevi Nimmanapalli, D Phil, Dipl ACVM, Associate Professor of Pharmaceutical Science;
黑料传送门 Georgia 鈥� 鈥淩ole of HSP70 in myeloma stromal cell interaction鈥�
- Eric Wang, PhD, Assistant Professor of Pharmaceutical Science; 黑料传送门 Georgia 鈥� 鈥淚dentification
of potential drug candidates for ameliorating oxidative stress involved ischemia reperfusion
injury鈥�
- James Wu, PhD, Assistant Professor of Pharmaceutical Science; 黑料传送门 Georgia 鈥� 鈥淭he
design and synthesis of amino acid or peptide prodrugs to improve delivery and targeting
of anticancer agents鈥�
- Mei Xu, MD, PhD, Assistant Professor of Anatomy; 黑料传送门 鈥� 鈥淓nhancement of axon regeneration
by localizing specific MRNAs鈥�
- Lindon Young, PhD, Associate Professor of Pathology, Microbiology, Immunology and
Forensic Medicine; 黑料传送门 鈥� 鈥淭he effect of triascin-C on leukocyte-endothelial interactions
by using intravital microscopy鈥�
- Christopher Adams, PhD, Associate Professor of Anatomy; 黑料传送门 鈥� 鈥淓ffect of liposuction
technique on the validity and differentiation of adipose derived stem cells鈥�
- Yun Bai, PhD, Assistant Professor of Pharmaceutical Science; 黑料传送门 Georgia 鈥� 鈥淣erve
growth factors intranasal delivery to the CNS for Alzheimer鈥檚 disease treatment鈥�
- Brian J. Balin, PhD, Professor of Pathology, Microbiology, Immunology and Forensic
Medicine; 黑料传送门 鈥� 鈥淭he role of tryptophan metabolism in C. pneumoniae infected monocytes:
Implications for Alzheimer鈥檚 disease鈥�
- Ruth Borghaei, PhD, Professor of Biochemistry and Molecular Biology; 黑料传送门 鈥� 鈥淓ffects
of nicotine and glucose on production of inflammatory mediators in response to IL-1
and LPS in human gingival fibroblasts and CAL27 oral cancer cells鈥�
- Qian Chen, PhD, Research Assistant Professor of Pathology, Microbiology, Immunology
and Forensic Medicine; 黑料传送门 鈥� 鈥淭he oxidative stress and inflammatory responses under
acute hypoglycemic conditions鈥�
- Marina D鈥橝ngelo, PhD, Associate Professor of Anatomy; 黑料传送门 鈥� 鈥淣ovel metalloprotease
peptide derivative therapeutics for osteoarthritis鈥�
- Susan Hingley, PhD, Professor of Pathology, Microbiology, Immunology and Forensic
Medicine; 黑料传送门 鈥� 鈥淐hanges in expression of genes associated with Alzheimer鈥檚 disease
and 尾-amyloid processing due to infection of neuronal cells by Chlamydia pneumoniae
and/or herpes simplex virus type 1鈥�
- Huo Lu, PhD, Assistant Professor of Anatomy; 黑料传送门 Georgia 鈥� 鈥淥ptogenetic study of
cerebellar circuit鈥�
- Harish S. Parihar, RPh, PhD, Assistant Professor of Pharmaceutical Science; 黑料传送门 Georgia
鈥� 鈥淒esign and synthesis of molecular probes for serotonin type 3 receptors and nicotinic
acetylcholine receptor architecture and molecular-level function鈥�
- Avadhesh Sharma, PharmD, PhD, Chair, Associate Professor of Pharmaceutical Science;
黑料传送门 Georgia 鈥� 鈥淜etamine-mediated modulation of NMDA and opioid receptors in activated
platelets鈥�
- Desuo Wang, PhD, Assistant Professor of Pharmaceutical Science; 黑料传送门 Georgia 鈥� 鈥淒ually
targeting L-type Ca2+ channel and type 4 phosphodiesterase for treatment of obesity鈥�
- Adwoa Aduonum, PhD, Assistant Professor of Physiology; 黑料传送门 Georgia 鈥� 鈥淢ethamphetamine
modulation of synaptic plasticity鈥�
- Brian J. Balin, PhD, Professor, Department of Pathology, Microbiology, Immunology
and Forensic Medicine; 黑料传送门 鈥� 鈥淢odulation of Chlamydia pneumoniae infection of THP1
cells following exposure to pDAG"
- Qian Chen, PhD, Research Assistant Professor, Department of Pathology, Microbiology,
Immunology and Forensic Medicine; 黑料传送门 鈥� 鈥淭he role of the protein kinase C beta II
in acute hyperglycemia induced leukocyte-endothelial interactions by using intravital
microscopy鈥�
- Marina D鈥橝ngelo, PhD, Associate Professor, Department of Anatomy; 黑料传送门 鈥� 鈥淓fficacy
of collagenase 3 peptides in abrogation of tissue destruction in an animal model of
osteoarthritis鈥�
- Kerin Fresa-Dillon, PhD, Professor,Department of Pathology, Microbiology, Immunology
and Forensic Medicine; 黑料传送门 鈥� 鈥淓fficacy of a vaccine against C. pneumoniae in prevention
of respiratory infection and/or respiratory spread鈥�
- Susan Hingley, PhD, Professor, Department of Pathology, Microbiology, Immunology and
Forensic Medicine; 黑料传送门 鈥� 鈥淚nvestigation of mouse hepatitis virus entry into host
cells using siRNA technology鈥�
- Harold L. Komiskey, PhD, Professor of Pharmacology; 黑料传送门 Georgia 鈥� 鈥淩esveratrol, estrogen,
and curcumin effect on manganese-induced toxicity of rat astrocytes鈥�
- Lindon H. Young, PhD, Associate Professor, Department of Pathology, Microbiology,
Immunology and Forensic Medicine; 黑料传送门 鈥� 鈥淭etrahydrobiopterin (BH4) and dihydrobiopterin
(BH2) in leukocyte-endothelium interactions by using intravital microscopy鈥�
- Adwoa Aduonum, PhD, Assistant Professor of Physiology; 黑料传送门 Georgia 鈥� 鈥淢ethamphetamine
modulation of synaptic plasticity鈥�
- Denah Appelt, PhD, Professor, Department of Neuroscience, Pharmacology and Physiology;
黑料传送门 鈥� 鈥淐hlamydophila (Chlamydia) pneumoniae (Cpn) promotes Ab 1-42 amyloid processing
in neuronal cells: A pathogenic trigger for Alzheimer鈥檚 Disease鈥�
- Brian J. Balin, PhD, Professor, Department of Pathology, Microbiology, Immunology
and Forensic Medicine; 黑料传送门 鈥� 鈥淎nalysis of Chlamydia pneumoniae Infection and Alzheimer鈥檚
disease pathology in the human olfactory system鈥�
- Denise Burns, DO, Assistant Professor, Department of Osteopathic Manipulative Medicine;
黑料传送门 鈥� 鈥淭he effects of osteopathic manipulation versus laser treatments on hypothyroidism鈥�
- Qian Chen, PhD, Research Assistant Professor, Department of Pathology, Microbiology,
Immunology and Forensic Medicine; 黑料传送门 鈥� 鈥淧KC isoform inhibition in leukocyte-endothelium
interactions by using intravital microscopy鈥�
- Farzaneh Daghigh, PhD, Associate Professor, Department of Biochemistry and Molecular
Biology; 黑料传送门 鈥� 鈥淒etermination of the physiologically and pathophysiologically relevance
of arginase isoforms in NO production by human gingival fibroblasts鈥�
- Marina D鈥橝ngelo, PhD, Associate Professor, Department of Anatomy; 黑料传送门 鈥� 鈥淭he protease
sensitive hinge region of LTBP1 is a substrate for MMP-13鈥�
- Randal Gregg, PhD, Assistant Professor, Dept. of Pathology, Microbiology, Immunology
and Forensic Medicine; 黑料传送门 Georgia 鈥� 鈥淢odeled microgravity effect upon dendritic
cell activation of tumor-specific CD8+T cells and melanoma growth鈥�
- Francis E. Jenney, Jr, PhD, Assistant Professor, Department of Biochemistry; 黑料传送门
Georgia 鈥� 鈥淯tilization of a small, hyperstable iron-protein, Pyrococcus furiosus rubredoxin,
as a medical diagnostic and therapeutic tool鈥�
- Michael L. Kuchera, DO, Professor and director, OMM Research/Human Performance and
Biomechanics Laboratory; 黑料传送门 鈥� 鈥淎 multi-center pilot study to evaluate the effect
of a pelvic orthotic and OMT protocol to reduce the impact of postural decompensation
in L5-S1 isthmic spondylolisthesis subjects with chronic, recurrent low back pain鈥�
- Michael McGuinness, PhD, Associate Professor, Department of Anatomy; 黑料传送门 鈥� 鈥淓strogen
regulation of cell adhesion molecules and their role in Sertoli cell-spermatogenic
cell interaction鈥�
- Mary P. Owen, PhD, JD, Associate Professor, Department of Pharmacology; 黑料传送门 Georgia
鈥� 鈥淐ontrol of retinal arteriole smooth muscle vasodilation: Exploring the role of
glucose, PGI2, BKca channels, and extravascular pressure鈥�
- Lindon H. Young, PhD, Associate Professor, Department of Pathology, Microbiology,
Immunology and Forensic Medicine; 黑料传送门 鈥� 鈥淎dministration of protein kinase C beta
II Inhibitor during extracorporeal shock wave lithotripsy reduces free radical production鈥�
- Denah Appelt, PhD, Professor, Department of Neuroscience, Pharmacology and Physiology;
黑料传送门 鈥� 鈥淓ffects on the apoptotic markers following a Chlamydial infection in neurons
and astrocytes: implications for Alzheimer鈥檚 disease鈥�
- Marina D鈥橝ngelo, PhD, Associate Professor, Department of Anatomy; 黑料传送门 鈥� 鈥淗ypertrophic
chondrocytes produce a large latent TGFb complex that includes MMP13鈥�
- Stephanie H. Felgoise, PhD, ABPP, Associate Professor and Vice Chair, Department of
Psychology; 黑料传送门 鈥� 鈥淨uality of life, coping, and psychological well-being in children
with LQTS and their primary caregivers鈥�
- Katherine D. Galluzzi, DO, CMD, FACOFP, Professor and Chairperson, Department of Geriatric
Medicine; 黑料传送门 鈥� 鈥淭he physician鈥檚 role in death: utilizing SP program to bring issues
to life鈥�
- Susan T. Hingley, PhD, Professor, Department of Pathology, Microbiology, Immunology
and Forensic Medicine; 黑料传送门 鈥� 鈥淒evelopment of a real-time PCR assay for the investigation
of viral entry mechanisms鈥�
- C. Scott Little, PhD, Assistant Professor, Department of Pathology, Microbiology,
Immunology and Forensic Medicine; 黑料传送门 鈥� 鈥淒evelopment and immune modulation of peanut
allergy in BALB/c and C3H/HeJ mice鈥�
